Investigating G protein-coupled receptor function in vivo using the olfactory system of a fish as a model.

Master Thesis subject (30 ECTS)
Olfactory receptors in vertebrates belong to the G protein-coupled receptor (GPCR) superfamily. This family is large, diverse and extremely important as it includes many neurotransmitter and hormone receptors. The ongoing research theme is to establish the olfactory system of fish as a model for studying GPCR function in vivo; the relative ease with which the electro-olfactogram (EOG) can be recorded from the olfactory epithelium of fish means that the function of these receptors can be investigated in vivo directly. Current projects include the identification of pheromones, characterization of transduction pathways, identification of ligand-receptor pairs, and the effects of acidification on olfactory sensitivity, in both marine and freshwater fish; however, the exact theme of the student’s project will depend on timing (i.e. what experiments are currently running) and the particular interests of the student.
Interest in animal physiology. Some practical experience would be welcome.
Number of students: 
academic year: 
Contact person email: 
contact person first name: 
Peter Hubbard
Reference Number: RP-35462